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Indication & Dosage |
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| Oral |
| IRRITABLE BOWEL SYNDROME |
| Adult:
(Clid BR 2.5mg + CDZ 5mg) 1-2 tab 3 or 4 times a day and at bed time. Elderly: Minimal effective dose. |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take 1/2-1 hr before meals.) |
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| Precautions |
Driving, hazardous work, elderly, renal disease, hepatic disease, hypertension, CVS disease, ulcerative colitis, hernia, reflux esophagitis, elderly and debilitated, autonomic neuropathy. |
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Potentially Life-threatening
Adverse Drug Reactions |
Mouth dryness, blurring, hesitancy and urgency in micturition, constipation, rise in body temperature, heat stroke, tachycardia, mydriasis, headache, nervousness, drowsiness, weakness, nausea, aggression, dependence, mild skin rashes and impaired psychomotor performance. |
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| Adverse Drug Reactions |
Severe hypersensitive reaction, hemolytic anemia (rarely). |
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| Interactions |
Alcohol potentiates chlordiazepoxide and concurrent use of both can be potentially dangerous. Cimetidine increases T½ of chlordiazepoxide. Absorption of chlordiazepoxide enhanced by metoclopramide and aluminum hydroxide. Chlordiazepoxide absorption hindered by Mg trisilicate, morphine and pethidine. Clidinium faces additive anticholinergic effects with antidepressants, quinidine and some antihistamines. |
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